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Healthcare online Keeping you up-to-date
VOL.  24     ISSUE: 8  August  2026 Medical Services Department

SQUARE Pharmaceuticals PLC.

Features

EDITORIAL TEAM

A S M Shawkat Ali
MBBS, M.Phil
Rezaul Hasan Khan
MBBS, MPH, FIPM,MSc
Rubyeat Adnan
MBBS, MPH, CCD
Moshfiqur Rahman
MBBS
Moinul Islam
MBBS

EDITORIAL

Dear Doctor,

Hope you are enjoying this healthcare online !
Our current health bulletin issue focused on some latest features like -


"
Microbial Legacy !", "Road Noise, Rising Risk !", "Screen Time !", "Protein Breakthrough !",  "Hidden Hormones !", "Female Resilience !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals PLC. as well.

We appreciate your feedback !

Click on to reply mode.

Yours sincerely,

 

Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals PLC.

 Microbial Legacy !

Early-Life Antibiotics May Shape Lifelong Allergy Risk

New research suggests that early-life antibiotic exposure may have lasting effects on the immune system by disrupting the newborn gut microbiome, potentially increasing the risk of allergies and asthma later in life. Researchers found that antibiotics can reduce beneficial gut bacteria that produce butyrate, a short-chain fatty acid essential for healthy immune development. In animal studies, the absence of butyrate led to a significant increase in innate lymphoid cells (ILC2s), which stimulate immune pathways associated with allergic reactions. The study revealed that this immune cascade promotes the production of allergy-related antibodies, making the immune system more likely to overreact to harmless substances such as pollen and pet dander. Without butyrate, each step in this inflammatory pathway became markedly amplified. These findings provide new insights into how the infant gut microbiome influences lifelong immune health and identify several potential targets for future therapies. While the research was conducted in mice, it highlights the importance of preserving healthy gut bacteria during early life and may pave the way for new strategies to prevent or better manage allergic diseases in the future.

SOURCE: American Academy of Neurology, August 2026

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 Road Noise, Rising Risk !

 Road Traffic Noise May Increase Hypertension Risk

Growing evidence suggests that road traffic noise is more than a nuisance—it may also contribute to the development of hypertension. A large prospective study involving more than 240,000 adults aged 40–69 years, who were initially free of hypertension, found that long-term exposure to road traffic noise was associated with a higher risk of developing high blood pressure over a median follow-up of 8.1 years. Researchers estimated traffic noise exposure using residential addresses and the Common Noise Assessment Method, a standardized European noise-modeling tool. The findings revealed a clear dose-response relationship, with hypertension risk increasing as noise exposure intensified. Importantly, this association remained significant even after adjusting for exposure to fine particulate matter (PM2.5) and nitrogen dioxide. The highest risk was observed among individuals exposed to both high traffic noise and air pollution, indicating that these environmental factors may act together to adversely affect cardiovascular health. As the first large-scale prospective study to directly examine the relationship between road traffic noise and newly diagnosed hypertension, these findings strengthen the evidence supporting public health measures aimed at reducing environmental noise. Strategies such as stricter noise regulations, improved urban planning, better road infrastructure, and quieter vehicle technologies may help reduce the cardiovascular burden associated with traffic noise. Researchers are continuing further studies to better understand the biological mechanisms through which road noise influences blood pressure.

SOURCE: Science daily News, August 2026

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 Screen Time !

Screen Time Plus Snacking May Increase Metabolic Risk in Teenagers

Excessive screen time combined with unhealthy snacking may significantly increase the risk of metabolic syndrome in teenagers, according to a large nationwide study. Metabolic syndrome is a cluster of conditions including high blood pressure, elevated blood sugar, excess abdominal fat, and abnormal cholesterol or triglyceride levels that increase the risk of heart disease, stroke, and type 2 diabetes. The study, conducted as part of Brazil's Study on Cardiovascular Risks in Adolescents (ERICA), analyzed data from 33,900 adolescents aged 12–17 years. Researchers assessed waist circumference, blood pressure, blood glucose, HDL cholesterol, and triglyceride levels to evaluate metabolic health.
The findings revealed that 85% of teenagers regularly consumed snacks while watching television, while 64% snacked during computer use or video gaming. Importantly, there was no significant association between screen time and metabolic syndrome among adolescents who did not snack while using screens. However, among those who habitually ate snacks during screen time, the risk of metabolic syndrome increased as the duration of screen exposure became longer.
These findings suggest that reducing unhealthy snacking during screen time may be as important as limiting screen time itself. Encouraging healthier eating habits and promoting active lifestyles may help reduce the growing burden of metabolic disorders among adolescents.

SOURCE: Science daily News, August 2026

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Protein Breakthrough !

'Undruggable' Cancer Protein Becomes a Promising Therapeutic Target

RA breakthrough in cancer research has identified a promising compound that may target BRAT1, a protein previously considered “undruggable” due to its challenging chemical properties. The compound, Curcusone D, has demonstrated potential against cancers in which BRAT1 plays a role, including breast, brain, colorectal, prostate, lung, and liver cancers.
Curcusone D is a naturally occurring compound derived from Jatropha curcas, a medicinal plant traditionally used in several cultures. Researchers successfully synthesized the compound in the laboratory and confirmed it as the first known inhibitor of BRAT1, overcoming the limitations of extracting only tiny amounts from the plant. In laboratory studies, Curcusone D effectively suppressed the growth of breast cancer cells, highlighting its potential as a novel anticancer agent. Laboratory synthesis also makes large-scale production feasible, an important step toward future drug development. Before clinical use, the compound must undergo further testing to establish its safety and effectiveness in humans. Nevertheless, this discovery opens new possibilities for targeting previously inaccessible cancer proteins and may contribute to the development of innovative treatments across multiple cancer types.

SOURCE: Science daily News, August 2026

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 Hidden Hormones !

Endocrine Disruptors May Threaten Future Semen Quality

 Emerging research suggests that exposure to endocrine-disrupting chemicals (EDCs) during pregnancy may have long-term effects on male reproductive health. EDCs are natural or synthetic chemicals that can interfere with the body's hormonal system and potentially affect the health of both mothers and their children. A study involving approximately 3,000 young men examined semen quality in relation to their mothers' occupational exposure to endocrine disruptors during pregnancy. The findings indicated that men exposed in utero were nearly twice as likely to have semen volume and other semen parameters below the World Health Organization (WHO) reference values. Previous animal studies have also shown that prenatal exposure to certain endocrine disruptors can impair the development of the male reproductive system and reduce sperm production in adulthood. Although these findings do not confirm future infertility, they suggest a significant association between maternal exposure to endocrine-disrupting chemicals and reduced semen quality later in life. The researchers emphasize the importance of raising awareness among women who are planning pregnancy or are in early pregnancy about potential occupational and environmental exposure to endocrine disruptors. Further research is also needed to better understand their long-term effects on female reproductive health.

SOURCE: Science daily News, August 2026

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Female Resilience !

Female Protective Effect May Explain Sex Differences in Autism 

Autism spectrum disorder (ASD) is diagnosed more frequently in boys than girls, and growing evidence suggests that girls may have a greater biological resilience to developing the condition. A recent study provides new insights into the “female protective effect,” indicating that girls may require a greater genetic burden to develop autism than boys. Researchers studied a balanced group of children and adolescents aged 8–17 years, including boys and girls with and without autism. Using functional magnetic resonance imaging (fMRI), they found that brain regions involved in social perception appeared to function differently in girls with autism than in boys, suggesting distinct neural pathways underlying the condition. Genetic analysis further revealed that girls with autism carried a higher number of genetic mutations, including copy number variations affecting genes expressed in the striatum, a brain region associated with behavior and reward processing. These findings support the hypothesis that girls may need a larger “genetic hit” before autism develops. Although further research is needed, the study highlights important sex-related differences in the biology of autism. A better understanding of the female protective effect may improve future diagnostic approaches, promote earlier identification of girls with autism, and contribute to more personalized strategies for care and intervention.

SOURCE: Science daily News, August 2026

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Products of SQUARE Pharmaceuticals PLC.

Product Methomol TM  
Generic Name Methocarbamol
  Strength 500 mg
  Dosage form Tablet
  Therapeutic Category CNS
Product D-balance O-SolutionTM
Generic Name

Colecalciferol 

Strength 2000 IU/ml
Dosage form Oral Solution
Therapeutic Category Plain Vitamin
Product Pepnor SyrupTM
  Generic Name Jirakadyarista Gastroprokinetic
  Strength 2.64 gm/5 ml
Dosage form Syrup
  Therapeutic Category Gastroprokinetic

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